Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive). This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19, by analyzing associations between treatments and outcomes. All data are collected in electronical records during routine practice.
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive). This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19. Risk factors which will be studied include: baseline characteristics such as medical history and drugs with corresponding administration protocols. Main outcomes include all-cause mortality, need for mechanical ventilation, for ICU transfer and all relevant biological syndromes. All data are collected in electronical records during routine practice and additional data may be collected retrospectively.
Study Type
OBSERVATIONAL
Enrollment
143
Centre Hospitalier Intercommunal Robert Ballanger
Aulnay-sous-Bois, France
RECRUITINGGroupe Hospitalier Pitie Salpetriere
Paris, France
NOT_YET_RECRUITINGComposite of death and mechanical ventilation
Composite of death and mechanical ventilation
Time frame: At 14-days follow-up
Need for mechanical ventilation
Need for mechanical ventilation
Time frame: At 14-days follow-up
Death
All-cause mortality
Time frame: At 14-days follow-up
Acute kidney injury
As defined by AKIN
Time frame: At 14-days follow-up
Acute respiratory distress syndrome
As defined by Berlin criteria: P/F ratio below 200, with PEEP \> +5 cmH20, radiologic findings compatible with ARDS and not explained by heart failure, occurring within 7 days of an acute pulmonary or non-pulmonary aggression.
Time frame: At 14-days follow-up
Cardiac arrhythmia and conduction disorder
Documented by EKG monitoring
Time frame: At 14-days follow-up
Composite of death and mechanical ventilation
Composite of death and mechanical ventilation
Time frame: Up to 60 days after inclusion
60-days mortality
All cause mortality at 60 days follow-up whenever possible
Time frame: Up to 60 days after inclusion
60-days mechanical ventilation
If patient was mechanically ventilated within 60 days of inclusion
Time frame: Up to 60 days after inclusion
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