Pentraxin-3 in Hysterectomy Patients

Muğla Sıtkı Koçman University40 enrolled

Overview

Comparison of the Tissue Trauma Markers Following Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy

Acute trauma and major surgeries activate a series of cascades to evoke systemic inflammatory response. The magnitude of the resulting inflammatory response is proportional to the severity of the tissue trauma. Abdominal or laparoscopic technique is widely used for the purpose of hysterectomy surgery. It is crucial for many aspects to compare these two techniques of hysterectomy in terms of the surgery-induced trauma. In this study, the severity of the inflammatory response resulting from the tissue trauma due to the techniques of TLH+BSO and TAH+BSO applied in our department were compared based on the PTX-3 molecule.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Laparoscopic Hysterectomy Abdominal Hysterectomy

Interventions

PTX-3DIAGNOSTIC_TEST

Pentraxin-3 ng/mL PTX-3 levels were measured using human PTX3 ELISA Kit 96 Tests/Box (Cat. No: CK-E90303) (Hangzhou Eastbiopharm Co.,Ltd., PRC) read by a ELISA device matching with the kit. For the purpose of measurement, microplate washer RT 2600 device and Rayto microplate reader RT 2100C device were used.

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: ·TLH+BSO patients and TAH+BSO patients Exclusion Criteria: * History of a chronic disease (coronary artery disease, diabetes mellitus, hypertension, coronary liver failures, chronic kidney disease, chronic respiratory diseases, connective tissue disorders) which may affect levels of PTX-3 and other inflammatory markers. * Prior surgery due to malignancy. * History of an intra-abdominal surgery, except for cesarean section. * History of any disease which may lead to intra-abdominal adhesions (endometriosis, past pelvic infection).

Outcomes

Primary Outcomes

Pentraxin-3 level

Pentraxin-3 ng/mL

Time frame: Before 24 hours preoperatively and upto 24 hours postoperatively

Secondary Outcomes

(NLR)

neutrophile/lymphocyte ratio

Time frame: Up to 24 hours postoperative

Data from ClinicalTrials.gov

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