RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial

SVS Institute of Dental Sciences40 enrolled

Overview

This study evaluated the regenerative potential of rhBMP-2 gel in intrabony defects when compared to sticky bone (control).

It was done in 40 subjects who were evaluated for a period of 6 months. the results were evaluated clinically (CAL, PPD) and radiographically (bone fill) and after 6 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Periodontitis

Interventions

BMP-2DRUG

lyophilized Human Bone Morphogenetic Protein-2 was used as an active drug.

PRFPROCEDURE

For the preparation of sticky bone, the patient's venous blood is collected and centrifuged at 2400rpm for 2min which leads to two different layers in the vacutainer the upper autologous fibrin glue (AFG) and the lower RBC portion, the upper AFG is mixed with a particulate bone graft (hydroxyapatite). Within 5-10 min fibrin meshwork was formed

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Systemically healthy male and female patients age 20-55 years with intrabony defects and probing pocket depth of ≥5mm after initial therapy were included in the study. Exclusion Criteria: * Medically compromised patients, Subjects who underwent radiotherapy or chemotherapy and smokers were excluded.

Locations (1)

SVS Institute of Dental Sciences, Mahabubnagar

Hyderabad, Andhra Pradesh, India

Outcomes

Primary Outcomes

bone fill

bone fill evaluation done after 6 months by using ImageJ® software

Time frame: 6 months

Data from ClinicalTrials.gov

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