Prono Position and Mechanical Power

Sanatorio Anchorena San Martin45 enrolled

Overview

The primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning while mantaining the same ventilatory setting. The secondary objetive of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning and adjusting an individualized ventilatory setting.

Data of mechanical power will be collected prospectively in three different times: 1. In supine positioning (T0). 2. After 15 minutes of having implemented prone positioning while maintaining the same ventilatory settings that in supine (T1). 3. In prone positioning after 15 min of having adjusted an individualized ventilatory setting (T2). Besides, the investigators will take an arterial blood sample in T0 and T2 to calculate changes in oxygenation status and ventilatory ratio. In case that esophageal manometry is available, the investigators will collect data regarding to transpulmonary and esophageal pressure in order to calculate the mechanical power applied to the lung parenchyma.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Respiratory Distress Syndrome

Interventions

Prone positionOTHER

The patients will be put in prone position while receiving invasive mechanical ventilation and the investigators will monitor changes in mechanical power applied to the respiratory system and compare with supine position

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged older than 18 years old under invasive mechanical ventilation with diagnostic criteria of acute respiratory distress syndrome acording to berlin definition and neccesity of prone positioning. Exclusion Criteria: * Need to interrump prone positioning maneuver. * Inability to collect data for any reason.

Locations (1)

Sanatorio Anchorena de San Martin

San Martín, Buenos Aires, Argentina

Outcomes

Primary Outcomes

Mechanical power of the respiratory system measured in supine compared with prone position while maintaining the same ventilatory setting

Mechanical power measured in Joules/min

Time frame: 1) Supine position; 2) Prone position, after 15 min

Secondary Outcomes

Mechanical power of the respiratory system measured in supine compared with prone position after adjusting the ventilatory setting

Mechanical power measured in Joules/min

Time frame: 1) Supine position; 2) Prone position, after 15 min of adjusting ventilatory setting.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.