Hepassocin Levels in Patients With Polycystic Ovary Syndrome

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Overview

The investigators aimed to investigate hepassocin levels in patients with polycystic ovary syndrome (PCOS). There are 3 groups aged between 18 and 35 years as non-obese healthy women, non-obese women with PCOS, and obese women (BMI\>30) with PCOS.

Hepassocin, also known as Fibrinogen-like-protein or hepatocyte-derived fibrinogen-related protein 1, is a new marker for obesity and insulin resistance. In hepatic injury, it protects liver cells and promotes regeneration. High levels of hepassocin was shown to be independently associated with HOMA-IR and diabetes. Since insulin resistance is known to be seen in patients with PCOS, it may be expected that hepassocin levels may be higher in this group of patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1)Polycystic Ovary Syndrome Obesity Insulin Resistance

Interventions

hepassocinOTHER

hepassocin levels in polycystic ovary syndrome

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 60 patients with PCOS aged between 18 and 35 and age-matched 30 healthy women with BMI\<30 Exclusion Criteria: Premature ovarian failure (FSH \>30 mIU/mL), tumors secreting androgens, non-classical congenital adrenal hyperplasia, Cushing syndrome and irregular menses due to thyroid dysfunction (TSH \>5 mIU/L ), hyperprolactinemia, more than twofold high transaminase levels (\>70 U/L), patients with cigarette smoking, alcohol consumption, oral contraceptives use, medications that are affecting liver function test, insulin metabolism and lipid metabolism, patients with a history of chronic diseases such as diabetes mellitus, hypertension, chronic liver disease, chronic kidney disease, autoimmune disease, inflammatory disease, malignant disease, bleeding disorders, and thrombosis were also excluded. All the patients were beta-HCG, hepatitis B surface antigen, and hepatitis C antibody negative. \-

Locations (1)

Gaziosmanpasa Taksim Education and Research Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Hepassocin levels in patients with polycystic ovary syndrome

hepassocin levels should be increased in polycyctic ovary syndrome due to its relation with insulin resistance.

Time frame: January 2020-March 2020

Data from ClinicalTrials.gov

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