To study the effects of a low free sugar diet on lipid profile, glycemic indices, liver enzymes, inflammatory factors and hepatic steatosis and fibrosis in patients with Nonalcoholic fatty liver disease, 50 patients who referred to Gastrointestinal (GI) clinic with steatosis grade 2 and 3 will be randomly allocated to receive low free sugar diet or regular diet for 12 weeks; both groups will be advised to adherence the investigators' nutrition recommendation and exercise program too. At the first and the end of the intervention, lipid profiles, liver enzymes,glycemic indices, some inflammatory markers, and liver fibrosis will be assessed and compared between groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
low free sugar diet with nutrition and exercise recommendation
Azita Hekmatdoost
Tehran, Middle East, Iran
RECRUITINGNational Nutrition and Food Technology Research Institute
Tehran, Iran
RECRUITINGALT
serum level of Alanine transaminase
Time frame: 12 weeks
AST
serum level of Aspartate transaminase
Time frame: 12 weeks
GGT
serum level of Gamma glutaminase
Time frame: 12 weeks
TG
serum level of Triglyceride
Time frame: 12 weeks
Total cholesterol
serum level of total cholesterol
Time frame: 12 weeks
LDL-c
serum level of LDL-Cholesterol
Time frame: 12 weeks
HDL-c
serum level of HDL-Cholesterol
Time frame: 12 weeks
FBS
serum level of Fasting blood sugar
Time frame: 12 weeks
Insulin
serum level of Insulin
Time frame: 12 weeks
hs-CRP
Serum level of high-sensitive C-reactive protein
Time frame: 12 weeks
TNF-a
Serum level of Tumor necrosis factor-a
Time frame: 12 weeks
NF-kb
Activity of Nuclear factor-B in peripheral monocellular cells
Time frame: 12 weeks
Liver fibrosis
Liver fibrosis according to fibroscan exam
Time frame: 12 weeks
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