Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

The University of Texas Health Science Center, Houston44 enrolled

Overview

The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for 24h

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Physiological Effect of Drugs Morphine Analgesics Analgesics, Opioid Central Nervous System Depressants Narcotics

Interventions

2% lidocaine with 1:200,000 epinephrine and epidural morphineDRUG

Epidurals will be dosed with 2% lidocaine with 1:200,000 epinephrine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.

3% 2-chloroprocaine and epidural morphineDRUG

Epidurals will be dosed with 3% 2-chloroprocaine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. This is the critical component to bridge the latency period between the offset of 3% 2-chloroprocaine and the peak action of epidural morphine.Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * pregnant patients * live singleton pregnancy Exclusion Criteria: * BMI \>40 * obstructive sleep apnea * drug abuse * chronic pain * chronic opioid use * nonfunctioning epidural

Locations (1)

The University of Texas Health Science Center at Houston

Houston, Texas, United States

Outcomes

Primary Outcomes

Total Amount of Opioid Used

Time frame: 24 hours after epidural morphine administration

Secondary Outcomes

Total Amount of Opioid Used

Time frame: 12 hours after epidural morphine administration

Total Amount of Opioid Used

Time frame: 8 hours after epidural morphine administration

Total Amount of Opioid Used

Time frame: 4 hours after epidural morphine administration

Pain as Measured by a 11 Point Verbal Scale

scale ranges form 0-10, higher number indicating more pain

Time frame: 4,8, 12 and 24 hours after epidural morphine administration

Number of Participants Who Had Mild, Moderate or Severe Nausea as Measured by a 3 Point Scale

scale ranges from non,mild and moderate-severe

Time frame: 4,8, 12 and 24 hours after epidural morphine administration

Number of Participants Who Had Mild, Moderate or Severe Pruritis as Measured by a 3 Point Scale

scale ranges from non,mild and moderate-severe

Time frame: 4,8, 12 and 24 hours after epidural morphine administration

Time Until First Opioid Request

Time frame: Up to 48 hours after epidural morphine administration

Data from ClinicalTrials.gov

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