Dokimos Plus Aortic Valve Implant in 80 Patients Diagnosed With a Heart Valve Disease and Requiring Valve Replacement

Inclusion Criteria: 1. Patients over 18 2. Patients with the ability to understand the study requirements, be able to given written informed consent, and be willing and able to comply with the study requirements (including follow-up visits). 3. Patient candidates to an aortic bioprosthesis implantation according to the standard clinical practice guidelines. 4. Patients requiring isolated aortic valve replacement, or in combination with coronary artery bypass surgery and / or in combination with ascending aorta replacement surgery. 5. Women are eligible for the study if: a) are not pregnant or breastfeeding, b) are not of childbearing potential, c) if women of childbearing potential, a negative urine pregnancy test should be done within 48 hours before the intervention and must use an effective contraceptive method. Exclusion Criteria: 1. Cardiac surgery contraindications. 2. Patients who require other interventions than the isolated aortic valve replacement or with coronary artery bypass surgery and / or in combination with ascending aorta replacement surgery as concomitant procedure. 3. Patients with LVEF \< 30%. 4. Cardiac surgery reintervention. 5. Cardiogenic shock or hemodynamic instability within 24 hours prior to surgery. 6. Patient who are not willing to attend to the required follow-up visit. 7. Patients with active endocarditis (in the case of cured endocarditis, the presence of at least two negative blood cultures must be confirmed before their inclusion in the study). 8. Patient undergoing hemodialysis or with severe renal impairment (eGFR\<30ml/min/1,7m2). 9. Pregnant women. 10. Patients with hyperparathyroidism. 11. Life expectancy less than 2 years. 12. Patients with a history or diagnosis of a medical problem or psychiatric illness or disorder that, according to the investigator evaluation, would make the patient not eligible to participate in the study.