Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting

Inclusion Criteria: * Able to read and understand informed consent. * High initial clinical suspicion by physician based on signs and symptoms (fever, cough, myalgias, fatigue, shortness of breath) followed by RT-PCR for confirmation of COVID-19 diagnosis * Any gender * Age 60 years and older * Age 30-59 years with one or more of the following: * abnormal lung exam * abnormal oxygen staturation \<95% * abnormal chest x-ray or chest CT * persistent fever \>100.4 degrees Fahrenheit upon arrival to Emergency department (ED) * one of the following co-morbidities: hypertension, diabetes mellitus, history of coronary artery disease, chronic kidney disease (CKD), asthma, chronic obstructive pulmonary disease, current or former smoker, or morbid obesity (Body Mass Index ≥35) Exclusion Criteria: * Pregnant or breastfeeding female * Severe COVID-19 requiring admission for inpatient treatment * Need for any oxygen supplementation * Need for mechanical ventilatory support * History of oxygen supplementation dependency * History of cancer with ongoing chemotherapy or radiation therapy * Concurrent antimicrobial therapy * Known hypersensitivity to hydroxychloroquine or other 4-aminoquinoline compounds * Already taking hydroxychloroquine or chloroquine within 1 month * Known G6-PD deficiency * History of retinopathy * History of current cardiac diseases (heart failure, ventricular arrhythmias, Left bundle branch block and/or Right bundle branch block, QTc prolongation \>480ms), or family history of sudden cardiac death * Ongoing use of drugs that prolong the QTc interval (antipsychotics, antidepressants, class I and III antiarrhythmics, triptans) * Severe renal disease: glomerular filtration rate (GFR) \<30ml/min * Severe hepatic impairment (elevated total bilirubin \>2 mg/dL, decreased albumin \<2.8 g/dL, signs of jaundice and ascites.) * Active alcohol abuse (\>5 drinks per day or \>20 drinks per week.) * Seizure disorder, currently on medications * Known hypersensitivity to any tetracyclines.