Perioperative Muscle Relaxant and Postoperative Outcomes

Air Force Military Medical University, China999 enrolled

Overview

Muscle relaxant is usually needed for surgery. However, the optimal depth of neuro-muscular blockade is still on debate. Deep neuro-muscular blockade may benefit the patients during surgery, but may increase the risk of residual blockade after surgery. Residual blockade has been reported to increase risk of morbidity. In this study, we tend to observe the postoperative outcomes in patients undergoing abdominal surgery under general anesthesia. And to compare the outcomes in patients received different depth of neuro-muscular blockade.

Study Type

OBSERVATIONAL

Enrollment

999

Conditions

Postoperative Complications

Interventions

No Response to Train of Four StimulationOTHER

No response is observed during Train of Four stimulation monitoring during surgery

1-2 Response to Train of Four StimulationOTHER

1 to 2 response is observed during Train of Four stimulation monitoring during surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years old * Body mass \<18 kg/m2 * American Society of Anesthesiologists status I-II * Patients scheduled for elective laparoscopic colorectal or urological surgery * Patients received general anesthesia and muscle relaxant * Patients with written informed consent. Exclusion Criteria: * Second surgery during the same admission. * Outpatient surgery * Retroperitoneal laparoscopic surgery * Patients scheduled for mechanical ventilation after surgery * Patients scheduled for muscle relaxant other than rocuronium * Patients with pregnancy or planned for breeding * Patients who are involved in other studies

Locations (9)

First hospital of Beijing University

Beijing, Beijing Municipality, China

Xiehe Hospital of Fujian Medical University

Fuzhou, Fujian, China

First Afiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Tongji Hospital of Tongji Medical School

Outcomes

Primary Outcomes

Visual Analogue Scale of pain at rest at 24 hours after surgery

The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.

Time frame: from end of surgery to 24 hours after surgery

Visual Analogue Scale of pain at cough at 24 hours after surgery

The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain.

Time frame: from end of surgery to 24 hours after surgery

Secondary Outcomes

Incidence of patients suffering pain at 24 hours after surgery

Time frame: from end of surgery to 24 hours after surgery

Time to flatus

Time frame: from end of surgery to flatus, on an average of 3 days

Time to extubation of the endotracheal tube

Time frame: from end of surgery to removal of the endotracheal tube, on an average of 15 minutes

Incidence of major postoperative complications

Incidence of major postoperative complications (including myocardial ischemia, pulmonary infection, respiratory failure, brain ischemia)

Time frame: from end of surgery to discharge from the hospital, on an average of 5 days

Satisfaction score of the Surgeon to the condition during surgery

The satisfaction of the Surgeon is measured by a scale from 0-10. 0 is for extremely unsatisfied, 10 is for totally satisfied. Higher score means higher satisfaction. The surgeon is asked to give a number between 0 and 10 to describe his satisfaction.

Data from ClinicalTrials.gov

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