A Study to Determine the Safety and Attack Rate of the Seasonal Flu in Healthy Volunteers

Inclusion criteria: 1. Male or female, between 18 and 55 years old (extremes included) at screening. 2. In good physical and mental health as determined on the basis of medical history and general physical examination performed at screening. 3. Absent or low levels of detectable pre-existing antibodies to influenza virus subtypes, including as a minimum the challenge strain, as determined by a MNT titre of ≤ 20 at screening. 4. Negative urine test for selected drugs of abuse at screening and upon check-in at the clinical site. 5. Negative alcohol breath test 6. Female subjects should fulfil one of the following criteria: 1. At least 1 year post-menopausal (amenorrhea \>12 months and/or follicle-stimulating hormone (FSH) \> 30 mIU/mL) prior to screening; 2. Surgically sterile (bilateral oophorectomy, hysterectomy, or tubal ligation); 3. Will use contraceptives as outlined in inclusion criterion 8 from screening to discharge. 7. Female subjects of childbearing potential and male subjects who are sexually active with a female partner of childbearing potential must agree to the use of an effective method of birth control from screening to discharge. Exclusion criteria: 1. Subjects who have received any vaccination within the last 3 months prior to screening or influenza vaccine within the last 12 months prior to screening or who anticipate receiving this during the study. 2. Subjects with a diagnosis of influenza or influenza-like illness confirmed by a physician within the last 6 months prior to screening. 3. Subjects with a positive result for adventitious agent screening (qualitative PCR testing) for any respiratory virus or bacteria on Day -2. 4. Haematology and chemistry parameters, pulse rate and/or blood pressure, and ECG outside the reference range for the population studied and considered as clinical significant by the Investigator. 5. Has an acute or chronic medical condition