Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic. Among COVID-19 complications, in-hospital cardiac arrest (IHCA) was reported with a very poor outcome in a retrospective single-center study (0,7% of 30 days survival with good neurological outcome among IHCA patients with a resuscitation attempt), related to its natural course and management. The incidence of unexpected in-ICU cardiac arrest (ICUCA) due to COVID-19 is still unknown. Additionally, outcome of COVID-19 patients admitted in ICU for an out-of-hospital cardiac arrest (OHCA) is also undescribed. The objective this study is : * to report the incidence of ICUCA among patients hospitalized in French ICU for COVID-19. * to report morbidity and mortality among COVID-19 patients admitted alive in ICU for an OHCA or an IHCA. The secondary objective is to assess outcome and identify risk factors of ICUCA occurrence among patients admitted for COVID-19.
Retrospective and prospective multicentric observational registry in French intensive care units (ICU) including all consecutive adult patients admitted in ICU with a documented SARS-CoV-2 disease : * For an out-of-hospital or an in-hospital cardiac arrest (OHCA and IHCA respectively) * Or presenting an unexpected in-ICU cardiac arrest (ICUCA) Patients characteristics, cardiac arrest history and patients outcome will be recorded according to Utstein recommendations. Patients presenting an expected cardiac arrest in ICU related to withdrawal of life sustaining therapies (WLST) will be excluded.
Study Type
OBSERVATIONAL
Enrollment
186
Cardiopulmonary resuscitation
0 - no symptoms at all 1. \- no significant disability despite symptoms; able to carry out all usual duties and activities 2. \- Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance 3. \- Moderate disability; requiring some help, but able to walk without assistance 4. \- Moderately severe disability; unable to walk and attend to bodily needs without assistance 5. \- Severe disability; bedridden, incontinent and requiring constant nursing care and attention 6. \- Dead
CHU Caen
Caen, Calvados, France
Hôpital Privé St Martin
Caen, Calvados, France
CH Angoulème
Angoulême, Charente, France
CH Brive
Brive-la-Gaillarde, Corrèze, France
CHU Dijon
Dijon, Côte-d'Or, France
CH Etampes
Étampes, Essonne, France
Incidence of unexpected cardiac arrest
Percentage of unexpected in-intensive care unit cardiac arrest among COVID-19 patients admitted to intensive care unit
Time frame: 7 months
Charlson score
Diabetes, hypertension, smoking, dyslipidemia, coronary artery disease, chronic respiratory insufficiency, chronic heart failure, chronic renal insufficiency, chronic hepatic insufficiency, chronic neurological disease, cancer, malignant hemopathy. Charlson score's minimum and maximum values are 0 and 40 respectively, the lowest score corresponds to a better outcome.
Time frame: 7 months
Organ failure score at ICU admission and/or before unexpected in-ICU cardiac arrest
Respiratory failure, neurological impairment, circulatory failure, hepatic failure, haematological failure, renal failure. Sofa score's minimum and maximum values are 0 and 24, the lowest score corresponds to a better outcome
Time frame: 7 months
Etiology retained to explain cardiac arrest occurrence
Cardiac origin; Respiratory origin; Metabolic origin; unknown origin
Time frame: 7 months
Modified Rankin score (mRS) at ICU discharge, at hospital discharge and at 3 months
0 - no symptoms at all 1. \- no significant disability despite symptoms; able to carry out all usual duties and activities 2. \- Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance 3. \- Moderate disability; requiring some help, but able to walk without assistance 4. \- Moderately severe disability; unable to walk and attend to bodily needs without assistance 5. \- Severe disability; bedridden, incontinent and requiring constant nursing care and attention 6. \- Dead
Time frame: 3 months
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