Patients undergoing cardiac catheterization will be randomized to 3 groups: no anticoagulant, low dose anticoagulant and high dose anticoagulant.
Patients undergoing diagnostic cardiac catheterization via the trans-radial approach will be randomly allocated (1:1:1) to receive either low-dose UFH (25 IU/Kg -maximal dose 3,000 IU), high-dose UFH 50 IU/kg -maximal dose 5,000 IU) or N/S 0.9%. After 30 minutes, patients will undergo a gradual wrist band release. Hematoma and radial artery occlusion will be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
1,623
Hamilton Health Sciences
Hamilton, Ontario, Canada
RECRUITINGLondon Health Sciences Centre
London, Ontario, Canada
RECRUITINGradial artery occlusion
by ultrasound
Time frame: 1 hour
Hematoma> 5 cm
Hematoma at access site
Time frame: one hour post procedure
access site bleeding
any bleeding
Time frame: 1 hour
non access site bleeding
bleeding not related to access site, such as gastrointestinal
Time frame: 1 day
access site complications
pseudoaneurysm, arteriovenous fistula
Time frame: 1 day
wrist band duration
How long wrist band was on
Time frame: 3 hours
time to discharge
when patient was able to leave the post procedure care area
Time frame: 1 day
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