Efficacy and Safety of Early COVID-19 Convalescent Plasma in Patients Admitted for COVID-19 Infection

Inclusion Criteria: * Patient older than 18 years * CALL score ≥ 9 (progression risk score) * PCR-confirmed COVID-19 infection with equal or less than 7 days of symptoms (or imaging consistent with COVID-19 pneumonia and confirmed COVID-19 contact) * Any symptoms of COVID-19 infection * Admission due to COVID-19 infection * Signed informed consent * ECOG before COVID-19 infection 0-2 Exclusion Criteria: * PaFi \<200 or mechanical ventilation indication * Clinically relevant co-infection at admission * Pregnancy or lactation * IgA deficiency or IgA nephropathy * Immunoglobulin or plasma administration in the last 60 days * Contraindication to transfusion or previous allergy to blood-derived products * Do-not-resuscitate status * Patients receiving other investigational drug for COVID-19 in a clinical trial * Any condition, that in opinion of the investigator may increase the risk associated with study participation or interfere with the interpretation of study results.