Spread and Course of COVID-19 Infections

Goldhahn Jörg2,910 enrolled

Overview

The overall goal is to study the immune response to SARS-CoV-2 infection over the period of one year in the blood of a representative cohort of ETH students/employees.

Study Type

OBSERVATIONAL

Enrollment

2,910

Conditions

Covid-19 Virus Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ETH employee or ETH student and their family members living in the same household at the start of the study * Between 18 and 64 years of age at the start of the study * Signed informed consent Exclusion Criteria: * Age over 64 years at the start of the study * In quarantine or self-confinement at the start of the study * Active COVID-19 infection at the start of the study: * Diagnosed with a laboratory test * Suspected based on typical symptoms such as fever (\>38°C), acute pulmonary ex-acerbation or sudden loss of gustatory taste * The following medical condition * With continuous steroid therapy/ chemotherapy/immunsuppressive therapy * In treatment for cancer * With severe autoimmune disease

Locations (1)

ETH

Zurich, Switzerland

Outcomes

Primary Outcomes

seroprevalence as well as the titer of serum antibodies (IgM, IgG and IgA) targeting SARS-CoV-2 antigens

Time frame: 12 months

Secondary Outcomes

the property of peripheral blood mononuclear cells before and after an infection with SARS-CoV-2 as opposed to other pathogens

Time frame: 12 months

the property of IgM and IgA antibody titers against the nucleocapsid protein of SARS-CoV-2 in symptomatic as well as asymptomatic COVID-19 infections over the course of time following an infection

Time frame: 12 months

the immune response to common-cold (corona)virus and influenza virus infections in patients with COVID-19 infections

Time frame: 12 months

Data from ClinicalTrials.gov

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