Development and Validation of a Serum Biomarker for the Diagnostic Work-up of Asthma

N/ACompletedNCT04377958

KU Leuven117 enrolled

Overview

Serum samples of asthmatic patients will be screened for serum biomarkers

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

117

Conditions

Asthma Biomarkers

Interventions

Serum biomarker testingDIAGNOSTIC_TEST

Serum and sputum samples will be collected and biomarkers will be evaluated using ELISA

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 - 65 years * physician-diagnosed asthma Exclusion Criteria: * No clear asthma phenotype * Presence of other pulmonary diseases (Chronic obstructive pulmonary disease, alfa-1-antitrypsine deficiency emphysema, Immunoglobulin E deficiency, allergic bronchopulmonary aspergillosis) * \> 15 pack years * No sputum available * Respiratory infection * Other inflammatory diseases (Rheumatoid Arthritis, Colitis Ulcerosa)

Outcomes

Primary Outcomes

Serum calprotectin

Serum Calprotectin (pg/ml) will be measured in serum samples using a U-plex assay

Time frame: Day 1

Secondary Outcomes

Sputum calprotectin

Sputum Calprotectin (pg/ml) will be measured in sputum samples using a U-plex assay

Time frame: Day 1

Data from ClinicalTrials.gov

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