Cross-linking as Treatment in Infectious Keratitis

Sohag University37 enrolled

Overview

To compare between SCXL and ACXL for treatment of infectious keratitis

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infectious Keratitis

Interventions

PACK-CXLPROCEDURE

Standard epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Fungal infectious keratitis * bacterial infectious keratitis * Must be not responding to medication Exclusion Criteria: * Viral keratitis * Pregnancy and lactation

Locations (1)

Faculty of medicine

Sohag, Egypt

Outcomes

Primary Outcomes

Corneal healing

Reepithelization of corneal ulcer which is measured in mm by slitlamp examination

Time frame: 3 months

Corneal edema

measurement of corneal edema by measurement of the corneal thickness in um by Optical Coherent Tomography

Time frame: 3 months

Data from ClinicalTrials.gov

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