The purpose of this research is to assess the impact of cannabis on the analgesic and abuse-related effects between men and women
The proposed study will compare smoked cannabis's dose-dependent, analgesic and abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharmacokinetics of THC.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
160
Smoked cannabis with THC
Placebo smoked cannabis (no THC)
University of California, Los Angeles
Los Angeles, California, United States
RECRUITINGSubject-rated drug effects
Average and peak subjective ratings of drug effects associated with abuse liability as measured using visual analogue scales (VAS; 1-100mm).
Time frame: 5 hours
Analgesia as measured using the Cold Pressor Test
Peak and average pain threshold and tolerance assessed using the Cold Pressor Test
Time frame: 5 hours
Pharmacokinetics of THC and metabolites
Plasma levels of THC, 11-OH-THC, and THCCOOH
Time frame: 5 hours
Drug reinforcement using the cannabis self-administration task
Average number of cannabis puffs self-administered as a function of cannabis strength and sex. For this task, up to three 'puffs' of cannabis may be chosen for self-administration during each session.
Time frame: 5 hours
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