Kidney Injury Severity and COVID-19

I.M. Sechenov First Moscow State Medical University340 enrolled

Overview

The authors hypothesize that the SARS-CoV-2 virus can affect the kidneys, causing them to be damaged. The present study aims to explain the mechanisms of kidney injury in patients diagnosed with COVID-19.

In December 2019, an outbreak of the 2019 novel coronavirus disease (COVID-19) caused by the SARS coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China. It has spread rapidly to other areas in China and worldwide. The most common manifestations of COVID-19 included fever, dry cough, dyspnea, myalgia, fatigue and radiographic evidence of pneumonia. Complications (acute respiratory distress syndrome, shock, acute cardiac injury, secondary infection, and acute kidney injury) and death may occur in severe cases. Recent reports showed that extrapulmonary symptoms (intestinal symptoms in 10-20% of patients) and renal failure in some patients may be associated with the interaction of the virus with angiotensin-converting enzyme 2 (ACE-2) receptors in other organs. It was suggested that ACE-2 expression in the kidneys can be the cause of kidney injury occurring in a number of patients with SARS-CoV-2.However, ACE-2 is not the only possible cause of kidney injury - sepsis-related cytokine storm can also lead to damage of kidney parenchyma. The present study aims to explain the mechanisms of kidney injury in patients diagnosed with COVID-19.

Study Type

OBSERVATIONAL

Enrollment

340

Conditions

COVID-19 Kidney Injury

Interventions

mRNA in urine testDIAGNOSTIC_TEST

Assessment of renal function, expression of viral RNA in urine and assessment of radiological changes will be performed

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pneumonia confirmed by CT scans Exclusion Criteria: * a history of chronic renal failure; * a history of kidney transplantation; * intake of substances with a history of renal toxicity (no later than a month before inclusion); * patients with a single kidney; * refusal of the patient to participate in the study; * absence of SARS-CoV-2 virus smear from the nasopharynx in PCR.

Locations (1)

Sechenov University.

Moscow, Russia

Outcomes

Primary Outcomes

The effect of COVID-19 severity on the severity of renal failure

estimated glomerular filtration rate (eGFR), ml/min, in groups with mild, moderate and severe COVID-19

Time frame: 2 months

Secondary Outcomes

The expression of viral RNA in the urine with the severity of renal failure

viral RNA concentration in urine, ME/ml

Time frame: 2 months

The severity of microalbuminuria in patients with COVID-19 of different conditions and renal failure

albumine excretion with urine, g/ml

Time frame: 2 months

Assessment of the severity of renal impairment in patients who died from COVID-19

estimated glomerular filtration rate (eGFR), ml/min

Time frame: 2 months

Estimation of the duration of urinary viral RNA isolation in patients undergoing COVID-19

Duration of viral RNA detection in urine by PCR, weeks

Time frame: 2 months

Expression of ACE-2 receptors in the kidneys of patients with renal failure who died from COVID-19

expression of ACE-2 by imminohistochemistry at autopsy specimen

Time frame: 2 months

Data from ClinicalTrials.gov

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