Multimodal Imaging in the Study of Disorientation in the Hospital

University Medical Center Rostock50 enrolled

Overview

The purpose of this study is to investigate whether markers of brain structure and function from MRI are associated with different levels of spatial orientation and gait parameters in people with mild cognitive impairment or dementia due to Alzheimer's disease when walking through a real world environment.

This is an experimental cross-sectional study which primarily aims at identifying characteristic features of spatial disorientation among people with mild cognitive impairment and dementia. The features of interest are motion and physiological related changes that occur during instances of spatial disorientation, which will be derived from wearable sensors. Additionally, brain structure and functional connectivity changes associated with different levels of spatial orientation and gait parameters will also be investigated through resting-state functional imaging.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mild Cognitive Impairment Dementia Disorientation Older Adults Magnetic Resonance Imaging

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 50 years and above * Mini mental state examination (MMSE) ≥ 12 \< 28 points for experimental group * Mini mental state examination (MMSE) ≥ 28 points for control group * Sufficient knowledge of German to understand participant information, declaration of consent and questionnaires * Dated and signed declaration of consent * Sufficient mobility and motivation to participate in the study Exclusion Criteria: * Less than 50 years * Significantly impaired vision or hearing * Severely reduced mobility: cannot move around independently (even with aids)

Locations (1)

Clinic and Polyclinic for Psychosomatics and Psychotherapeutic Medicine, University Medical Center Rostock

Rostock, Mecklenburg-Vorpommern, Germany

RECRUITING

Outcomes

Primary Outcomes

Spatial disorientation

Incidences of disorientation will be annotated in real-time using a customized annotation scheme in the pocket observer software