Emerging in China in December 2019, Covid-19, whose pathogen is SARS-Cov-2, was declared a global pandemic in March 2020. The clinical presentation is highly variable, ranging from asymptomatic forms to acute respiratory distress and even death. Transmission occurs through droplets, with a R0 of approximately 3. Rapidly, population protection measures were put in place by governments, including the confinement of all persons whose functions were not considered essential and the closure of educational institutions. Health care institutions are places at risk of Covid-19 transmission and hospital staff are particularly exposed, either through direct contact with patients, contact with exposed persons or through the environment. In order to protect personnel, hygiene measures were immediately recalled and reinforced. This study is aimed at evaluating the incidence rate of anti-SARS-Cov2 seroconversion over 2 months among hospital staff, without any supposed anti-Covid treatment 19.
Study Type
OBSERVATIONAL
Enrollment
845
A blood sample is collected by venipuncture at Day 0, Day 30 and Day 60. The anti-SARS-CoV2 serological status is measured by automated microplate ELISA technique on the EVOLIS analyzer (Biorad®), using reagent kits from EUROIMMUN France.
Data concerning personal exposure factors are collected in a questionnaire: * Socio-demographic factors: sex, age * Professional factors: Employment (type, pace, reception, service, care practices), wearing of personal protective equipment (type of equipment, frequency of use) and type of hospital * Non-professional factors: Contact with infected individuals, carrying of professional equipment and compliance with barrier measures
Hôpital d'Instuction des Armées Sainte-Anne
Toulon, France
Hôpital d'Instruction des Armées Robert Picqué
Villenave-d'Ornon, France
Anti-SARS-Cov2 seroconversion between Day 0 and Day 60.
Change of Anti-SARS-Cov2 serological status between Day 0 and Day 60, measured in blood sample.
Time frame: From Day 0 to Day 60
Anti-SARS-Cov2 seroconversion between Day 0 and Day 30.
Change of Anti-SARS-Cov2 serological status between Day 0 and Day 30, measured in blood sample.
Time frame: From Day 0 to Day 30
Anti-SARS-Cov2 seroconversion between Day 30 and Day 60.
Change of Anti-SARS-Cov2 serological status between Day 30 and Day 60, measured in blood sample.
Time frame: From Day 30 to Day 60
Anti-SARS-Cov2 seroprevalence at Day 0.
Anti-SARS-Cov2 seroprevalence measured in blood sample collected at Day 0.
Time frame: Day 0
Correlation between seroconversion and socio-demographic factors - sex
Correlation between seroconversion (measured in blood sample) at Day 60 and sex
Time frame: Day 60
Correlation between seroconversion and socio-demographic factors - age
Correlation between seroconversion (measured in blood sample) at Day 60 and age
Time frame: Day 60
Correlation between seroconversion and professional factors - job type
Correlation between seroconversion (measured in blood sample) at Day 60 and job type (nurse, physician, etc.)
Time frame: Day 60
Correlation between seroconversion and professional factors - personal protective equipment type
Correlation between seroconversion (measured in blood sample) at Day 60 and personal protective equipment type
Time frame: Day 60
Correlation between seroconversion and non-professional factors - contact with infected individuals
Correlation between seroconversion (measured in blood sample) at Day 60 and contact with infected individuals
Time frame: Day 60
Correlation between seroconversion and non-professional factors - wearing of professional equipment
Correlation between seroconversion (measured in blood sample) at Day 60 and wearing of professional equipment
Time frame: Day 60
Correlation between seroconversion and non-professional factors - respect of barrier gestures
Correlation between seroconversion (measured in blood sample) at Day 60 and respect of barrier gestures
Time frame: Day 60
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