Rapid Reinitiation of a Single Tablet Antiretroviral Therapy Using Symtuza® in HIV-1 Infected Treatment-Experienced Patients Off Therapy. (ReSTART)

Inclusion Criteria: * At least 18 years of age at screening/baseline visit. * Antiretroviral treatment-experienced and have not received any anti-HIV treatment within 12 weeks prior to screening. * Contraceptive use by men or women should be consistent with the local regulations regarding the use of contraceptive methods for subject participating in clinical studies. * Men must agree not to donate sperm during the study until 90 days after receiving the last dose of study drug (or longer, if dictated by local regulations). * Must be able to swallow whole tablets or swallow tablets cut into halves. Exclusion Criteria: * Known active cryptococcal infection, active toxoplasmic encephalitis, Mycobacterium tuberculosis infection, or another AIDS-defining condition that in the judgment of the investigator would increase the risk of morbidity or mortality. * Known resistance to any of the components of D/C/F/TAF; subjects with known or identified FTC resistance attributed to an M184V mutation alone will be permitted to remain in the study. * Prior virologic failure on a DRV-containing regimen from known history or from medical records. * Known history of clinically relevant hepatic disease or hepatitis that in the investigator's judgment is not compatible with D/C/F/TAF. * Known history of severe hepatic impairment as diagnosed based on documented history of severe hepatic impairment (Child-Pugh C). * Known history of chronic (≥3 months) renal insufficiency, defined as having an eGFR\<30 mL/min according to the MDRD formula. * Pregnant, or breast-feeding, or planning to become pregnant while enrolled in this study or within 90 days after the last dose of study treatment. * Plans to father a child while enrolled in this study or within 90 days after the last dose of study treatment. * Current alcohol or substance use judged by the investigator to potentially interfere with subject study adherence. * Known history of malignancy within the past 5 years or ongoing malignancy other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, noninvasive cutaneous squamous carcinoma. * Known active, severe infections (other than HIV-1 infection) requiring parenteral antibiotic or antifungal therapy that in the judgment of the investigator would increase the risk of morbidity or mortality. * Any other condition or prior therapy for which, in the opinion of the investigator, participation would not be in the best interest of the subject (e.g., compromise the wellbeing) or that could prevent, limit, or confound the protocol-specified assessments. * Subject unlikely to comply with the protocol requirements based on clinical judgment. * Received an investigational drug (including investigational vaccines) or used an invasive investigational medical device within 90 days before the planned first dose of study treatment or is currently enrolled in an investigational study. * Subjects receiving ongoing therapy with contraindicated, not recommended, drugs that cannot be adequately dose-adjusted, or subjects with any known allergies to the excipients of the D/C/F/TAF. * Employee of the investigator or study site, with direct involvement in the proposed study or other studies under the direction of that investigator or study site, as well as family members of the employees or the investigator, or employees of Johnson \& Johnson.