the Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease

Inclusion Criteria: 1. Subjects themselves and their legal representatives (or their immediate family members) voluntarily received the treatment and signed the consent form before this study; 2. Age ≧ 50 years, males and females; 3. Subjects diagnosed with Patients with mild or moderate Alzheimer's disease, based on the NIA/AA(2011). 4. The Mini-Mental Status Examination (MMSE) score was 10-24 (inclusive); 5. Modified Hachinski Ischemic Scale (MHIS) score was ≦ 4; 6. Suspension of cognitive-enhancing drugs and marketed therapeutic drugs such as ginkgo, high-dose vitamin E, lecithin, estrogen, non-steroidal anti-inflammatory drugs (NSAIDs), Donepezil, Memantine, etc ; 7. Based on medical history, physical examination, vital signs, laboratory tests and 12-lead electrocardiogram (ECG) results, subjects are generally in good condition; 8. Subjects can walk independently or receive outpatient follow-up with assistive devices (wheelchairs, walkers or crutches), while the subject's vision and hearing (allowing glasses and / or hearing aids) do not affect the follow-up procedure; 9. The subject has an identified and reliable caregiver who must also meet the following conditions: (1) In the hospital, caregiver can independently read and understand relevant research documents, and can do necessary communication with the investigator; (2) Caregiver can follow clinical research procedures and ensure that accurate information about the status of the subject can be provided during the study; (3) Caregiver live with the subject; or take care of the subject no less than 3 days a week and no less than 2 hours a day; 10. Female subjects with fertility (including women of childbearing age and women less than 1 year after menopause) were required to take effective contraception throughout the study. At the same time, urine pregnancy tests were negative during screening. Exclusion Criteria: 1. The subjects with more serious allergic constitution; 2. Received allogeneic mesenchymal progenitor cell therapy or its derived exosomes; 3. Laboratory test (any item meets): neutrophil absolute number \< 1.0 × 109 / L, platelet count \< 100 × 109 / L, serum albumin \< 30g / L, serum creatinine \> upper limit of normal value range, total bilirubin, alanine aminotransferase, aspartate aminotransferase \> upper limit of 2 times of normal value range; 4. The subject has serious and poorly controlled concomitant diseases, such as (but not limited to) cardiovascular, cerebrovascular, liver, kidney, lung, endocrine and other system diseases; 5. Severe Alzheimer's Disease; 6. Severe depression; 7. The subjects suffered from Parkinson's disease, multiple cerebral infarction, vascular dementia, Huntington's disease, hydrocephalus, progressive supranuclear paralysis, multiple sclerosis, epilepsy, mental retardation or major history of brain injury (with or without persistent neurological impairment) or known brain structural abnormalities; 8. The subject has an history malignant tumor； 9. The subject has severe generalized infectious diseases in the 3 months prior to this trial.; 10. The subject has contraindication of MRI, included but not only: the subject installed heart pacemaker, defibrillator, heart bracket, heart valve prosthesis, metal clip after aneurysm surgery, drug infusion device implanted in vivo, any electronic device implanted in the body (nerve stimulator, bone growth stimulator) endovascular coil, strainer, ECG monitor, metal suture, shrapnel or sand of body, plate fixation and steel nail after fracture surgery, artificial cochlea, middle ear shift plant, metallic intraocular foreign body etc; the subject is a claustrophobia, critical ill patient and so on. 11. The subject tests positive for: HIV, HBV, HCV and treponema pallidum; 12. The subject has history of alcoholism, drug abuse, or mental illness in the 10 years prior to this trial. 13. The subject has participated in any other clinical trial in the 6 months prior to this trial; 14. The female subjects are pregnant, lactating or pregnant in the past half a year; 15. The subject has any other unsuitable condition (such as factors reducing the follow-up compliance) to be determined by the investigator.