A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates

Postgraduate Institute of Dental Sciences Rohtak32 enrolled

Overview

This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.

Patients with apicomarginal defects as per the inclusion criteria will be randomly divided into two groups - (1) Test group - The denuded root surface will be covered by PRF (Choukron's method) and (2) Control group -No use of autologous platelet aggregate during periapical surgery. Radiographic and clinical healing will be assessed after 12 months, 2D healing will be assessed by Rud and Molven criteria and 3D healing will be assessed by Modified Penn 3D criteria.The clinical parameters recorded including periodontal pocket depth (PD), clinical attachment level (CAL) and gingival margin position (GMP) will be measured on buccal aspect of the interproximal space and mid buccal aspect of the involved teeth using Williams 'O' periodontal probe.Routine examination procedure will be used to evaluate any evidence of signs and/or symptoms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Apical Periodontitis

Interventions

Periapical surgery using autologous platelet aggregatePROCEDURE

PRF will be placed over the denuded root surface, following apicoectomy and before flap repositioning

Periapical surgery without autologous platelet aggregatePROCEDURE

Flap will be repositioned following apicoectomy directly without placing any platelet aggregate

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * A negative response to vitality tests with radiographic evidence of periapical radiolucency with no general medical contraindications for oral surgical procedures. * Apicomarginal communication having probing depth \> 6mm. * Patients with no general medical contraindications for oral surgical procedures. * Recurrent episodes of purulent discharge. * Failed previous root canal treatment. * Failed previous surgery with persistent bony lesion. * Adequate final restoration with no clinical evidence of coronal leakage. Exclusion Criteria: * Clinical or radiographic evidence of root fracture. * Resorptive processes involving more than apical third of the root. * Any systemic disease contraindicating oral surgery including uncontrolled diabetes and pregnancy. * Any condition effecting rate of healing like smoking.

Locations (1)

Ankita Ramani

Rohtak, Haryana, India

RECRUITING

Outcomes

Primary Outcomes

Change in periapical radiolucency

2 blinded caliberated operators will score the periapical radiolucency at baseline and 12 months by following scoring scores for 2D healing Score1-Complete healing defined by re-establishment of the lamina dura Score 2- Incomplete healing (scar tissue) Score 3- Uncertain healing Score 4- Unsatisfactory healing scores for 3D healing Score1- Complete healing Score 2- Limited healing Score 3- Uncertain healing Score 4- Unsatisfactory healing

Time frame: Baseline to 12 Months

Secondary Outcomes

Clinical success

Clinical success will be assessed by absence of clinical signs and symptoms such as pain, swelling , sinus or tenderness on palpation or percussion

Time frame: Baseline to 12 Months

Central Contacts

DR PANKAJ SANGWAN

CONTACT

9996112202 drps_1@yahoo.com

ANKITA RAMANI

CONTACT

9582841539 ramaniankita95@gmail.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.