Periorbital hyperpigmentation (POH) is a common condition in dermatology practice. Periorbital hyperpigmentation is defined as bilateral, round, homogeneous pigmented macules.The etiology of POH is multifactorial including genetic and enviromental factors. Many treatment options are avaiblabe with variable efficacy and safety in different patients. Therefore, the investigator's study aims to evaluate the efficacy and safety of combined microneedling with topical Glutathione versus Carboxy Therapy in treatment of patients with periorbital hyperpigmentation.
Periorbital hyperpigmentation (POH) is a common skin condition which has a great negative effect on the patient quality of life. Many factors contribute in the pathogensis of POH which lead to developement of several treatment options with no treatment option has a great sucess in improving the POH and patient quality of life. Our current study tries to explore the efficacy and safety between 2 treatment methods in a split face study. Microneedling is a process of making small punctres into the skin through small needles by device which is called a Dermapen. This microneedling method is beleived to be associated with improving the skin quality through increased collagen. This microneedling will be followed by topical application of glutathione which is a commong antioxidant with whitening effects. Carboxy therapy is a new emerging treatment option in many dermatological diseases. It will be used in POH patients as it will be able to increase blood flow in periorbital area and improve the skin qulaity.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
31
6 sessions of carboxy therapy every 2 weeks
6 sessions of Dermapen microneedling with topical glutathione every 2 weeks
Faculty of Medicine, Sohag University
Sohag, Egypt
Change of periorbital hyperpigmentation through photo evaluation
High-resolution photographs of both sides of the face were taken. Using a physician visual analog scoring system, 2 independent blinded dermatologists will rate the patient's overall aesthetic improvement as follows 1 (worse), 2 (no change), 3 (\<30%), 4 (30-60%), and 5 (\>60%)
Time frame: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment
Change of periorbital hyperpigmentation through dermoscopy evaluation
Dermoscopic evaluation was done using dermalite connection kit for Samsung galaxy. 2 independent blinded dermatologists will rate the patient's overall aesthetic improvement as follows * Vasculature improvement (No 0, Yes 1) \& percent of improvement. * Pigmentation improvement (No 0, Yes 1) \& percent of improvement. * Skin improvement like atrophy and exaggerated skin markings (No 0, Yes 1) \& percent of improvement.
Time frame: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment
Change of the patient satisfaction evaluation: scale
The patients were asked to evaluate their own level of satisfaction after they completed the study on a 1-3 scale: 1 = slightly satisfied, 2 = moderately satisfied, and 3 = well satisfied
Time frame: Baseline and 1 month after end of treatment
Change of periorbital hyperpigmentation into another skin problem through safety evaluation
Safety evaluation to detect precentage of side effects reported either by the patient or by the physician.
Time frame: Baseline, before 3rd session, before 5th session, 1 month after end of treatment, 2 months after end of treatment
The Dermatology Life Quality Index questionnaire
The Dermatology Life Quality Index questionnaire (DLQI) is 10 questions were asked to the patients and score is 0-3 for each question. The DLQI is calculated by summing the score of each question resulting in a maximum of 30 and a minimum of 0. The higher the score, the more quality of life is impaired.
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Time frame: Baseline, before 3rd session, before 5th session,