The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
Prospective, cross-over trial enrolling neonates \<28 weeks' gestation requiring MV. Patients were ventilated for 3 hours with pressure controlled assist-control (PC-AC) mode, followed by 3-hours of volume guarantee assist-control ventilation (VG-AC). Continuous monitoring was carried out using pulse oximetry (oxygen saturation - SpO2 and heart rate - HR), near-infrared spectroscopy (cerebral oxygenation - StO2) and electrical cardiometry (circulatory parameters).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
25
volume guarantee assist-control mechanical ventilation
pressure-controlled assist-control mechanical ventilation
Department of Neonatology at Poznań University of Medical Sciences
Poznan, Poland
StO2
Cerebral oxygenation measured using near-infrared spectroscopy \[percent\]
Time frame: 6 hours
Stroke volume
Stroke volume (SV) monitored with electrical cardiometry \[ml\]
Time frame: 6 hours
Cardiac output
Cardiac output (CO) monitored with electrical cardiometry \[L/min\]
Time frame: 6 hours
Stroke index
Stroke index (SI) monitored with electrical cardiometry \[ml/m2\]
Time frame: 6 hours
Cardiac index
Cardiac index (CI) monitored with electrical cardiometry \[L/min/m2\]
Time frame: 6 hours
Stroke volume variation (SVV)
Stroke volume variation (SVV) monitored with electrical cardiometry \[percent\]
Time frame: 6 hours
Index of contractility
Index of contractility (ICON) monitored with electrical cardiometry
Time frame: 6 hours
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