The objectives of the study, are to describe detection of SARS-CoV-2 in the semen of COVID-19 positive patients, the duration of positive semen and to investigate the impact on semen quality, thereby providing insights into the early impact on male reproductive function.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), a novel coronavirus reported in late December 2019 in Wuhan, China, has spread world-wide with over 1,000,000 coronavirus disease 2019 (COVID-19) cases reported. New developments in molecular virology and immunobiology of SARS-CoV-2, improve our understanding about COVID-19 prevention, management, and possible long-term effects. Although viral transmission occurs predominantly through respiratory droplets, SARS-CoV-2 has been isolated in blood samples and feces from COVID-19 patients, raising questions about viral shedding in other bodily fluids, including semen, as well as alternative modes of transmission. The objectives are to describe detection of SARS-CoV-2 in the semen of COVID-19 positive patients, the duration of positive semen and to investigate the impact on semen quality, thereby providing insights into the early impact on male reproductive function.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
20
SARS-CoV-2 positive men will be asked to give an ejaculated semen sample, within the seven days after positive testing. Semen samples will be performed every 7 days, until 2 semen PCR tests are negative and will be retested after 3 months.
UZ Brussel
Brussels, Belgium
RECRUITINGdetection of SARS-CoV-2 in the semen
detection of SARS-CoV-2 in the semen of men positive for SARS-CoV-2 on nasopharyngeal swab
Time frame: within 7 days after positive testing for SARS-CoV-2
duration of SARS-CoV-2 presence in semen
in case of a positive SARS-CoV-2 semen sample, for how long stays the virus present in semen
Time frame: from first positive semen testing until first negative semen testing, upto 15 weeks
semen viscosity
viscosity of semen will be assessed macroscopically
Time frame: from first until last semen analysis, upto 15 weeks
semen volume
semen volume
Time frame: from first until last semen analysis, upto 15 weeks
semen pH
semen pH
Time frame: from first until last semen analysis, upto 15 weeks
Sperm motility
Sperm motility assesment, according to the WHO guidelines of 2010
Time frame: from first until last semen analysis, upto 15 weeks
Sperm morphology
Sperm morphology assesment, according to the WHO guidelines of 2010
Time frame: from first until last semen analysis, upto 15 weeks
Sperm density
Sperm density assesment, according to the WHO guidelines of 2010
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Time frame: from first until last semen analysis, upto 15 weeks