Clinical and Immunological Features of the CMV Infection Atypical Course in Immunocompetent Individuals

The Republican Research and Practical Center for Epidemiology and Microbiology45 enrolled

Overview

Current study evaluates possible correlations between the content of various cell populations, the genetic material of the virus and antibodies to it in the blood of patients and the risk of thrombosis development in patients with acute CMV infection. А new method for the early detection of immunological and clinical signs of thromboembolic complications of CMV infection in immunocompetent individuals and the treatment of patients in this category will be developed.

* evaluate the immune status main indicators that characterize the activation of immune system, immunosuppression and anergy (myeloid suppressor cells, T-regulatory cells, T-cells according to the stages of differentiation (naive - effector - memory), activated T-cells); * identify and characterize immunological disorders in patients with CMV infection complicated by thromboembolism of various localization; * determine the presence and quantitative content in plasma / serum and neutrophils of the CMV genetic material by real-time PCR; * study humoral immunity to CMV (IgM / IgG antibodies to CMV in serum); * determine the content of CMV specific T-cells in peripheral blood; * develop a method for the early detection of immunological and clinical signs of thromboembolic complications of CMV infection in immunocompetent persons and treatment of patients in this category.

Study Type

OBSERVATIONAL

Enrollment

Conditions

CMV

Interventions

Determination of blood leukocyte subpopulations: myeloid suppressor cells, T-regulatory cells, T-cells according to the stages of differentiation (naive - effector - memory), activated T-cells; circulating endothelial cells

CMV specific T-cellsDIAGNOSTIC_TEST

CMV specific T-cells detected by flow cytometry

serum CMV IgM / IgG antibodiesDIAGNOSTIC_TEST

serum CMV IgM / IgG antibodies detected by ELISA

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 - 80 years; * fever of not clear etiology * confirmed CMV infection Exclusion Criteria: * HIV infection * taking hormones, cytostatics; * drug addiction * malignant neoplasms over the past 5 years. * active viral hepatitis or liver cirrhosis; * immunosuppressive conditions of any etiology

Locations (1)

The Republican Research and Practical Center for Epidemiology and Microbiology

Minsk, Belarus

Outcomes

Primary Outcomes

Number of patients with thrombosis

Thrombosis as a complication of CMV infection and its association with immune status, CMV specific T-cells count and CMV specific antibodies level

Time frame: 1 month

Data from ClinicalTrials.gov

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