Effects of Legumes Consumption on Weight Reduction

Yonsei University400 enrolled

Overview

This is a 12-week, randomized nutritional intervention study to determine the effect of legumes consumption on body weight in obese subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

400

Conditions

Obese

Interventions

Legume enriched diet groupBEHAVIORAL

* Replacing 1/3 refined rice intake with legumes three times per day * Vegetable intake at least six units (30-70 g/unit) per day for sufficient dietary fiber intake * Regular 30-min walk after dinner each day

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male and female volunteers between the ages of 20 to 70 years 2. Body mass index (BMI) of 25 kg/m2 or higher (based on Asia-Pacific guideline) 3. Volunteers who have agreed to participate in the study and provided a written content by him/herself Exclusion Criteria: 1. Those with type 2 diabetes, cardiovascular disease, psychiatric problems, thyroid disorders, liver or kidney disease 2. Those under the use of any medications (antihypertensive, lipid-lowering, antiplatelet, antidiabetic, etc.).

Outcomes

Primary Outcomes

Changes of BMI

Changes of weight in kilograms was assessed before and after the intervention. Changes of height in meters was assessed before and after the intervention. Weight and height were combined to report BMI in kg/m\^2.

Time frame: 12 weeks

Changes of Insulin Resistance (IR)

Changes of fasting serum glucose in mmol/L was assessed before and after the intervention. Changes of fasting insulin in μIU/mL was assessed before and after the intervention. Fasting insulin and fasting glucose were combined to report IR using the following equation: homeostasis model assessment (HOMA)-IR=\[fasting insulin (μIU/mL)×fasting glucose (mmol/L)\] /22.5.

Time frame: 12 weeks

Changes of lipid profiles

Triglyceride in mg/dL was assessed before and after the intervention. Total-cholesterol in mg/dL was assessed before and after the intervention. HDL-cholesterol in mg/dL was assessed before and after the intervention. LDL-cholesterol was indirectly estimated using the friedewald formula: LDL-cholesterol= total-cholesterol-\[HDL-cholesterol+(triglycerides/5)\].

Time frame: 12 weeks

Changes of serum high C-reactive

Changes of serum high C-reactive in mg/L was assessed before and after the intervention.

Time frame: 12 weeks

Changes of urinary 8-epi-PGF2α

Changes of urinary 8-epi-PGF2α in pg/mg creatinine was assessed before and after the intervention.

Time frame: 12 weeks

Changes of adiponectin

Changes of adiponectin in ng/mL was assessed before and after the intervention.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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