Endovascular Stenting of Medically Refractory ICASD (Clinical and Sonographic Study)

Inclusion Criteria: 1. Patients age between 30-80 years. 2. Symptomatic ICAS: presented with TIA or stroke, attributed to 70%-99% stenosis of a major intracranial artery: Internal carotid artery (ICA), middle cerebral artery (MCA) \[M1segment\], vertebral artery (VA), or basilar artery (BA). 3. Patient with recurrent TIA or stroke despite medical therapy, including anti-coagulation or antiplatelet and control of all vascular risk factors (DM, HTN and Hyperlipidemia). Exclusion Criteria: 1. Patients previously stented at the target lesion or had extracranial stenosis. 2. Patient with acute stroke (within two weeks from the onset). 3. Complete occlusion of the artery on the imaging assessment. 4. Massive cerebral infarction (more than half the MCA territory), intracranial hemorrhage, epidural or subdural hemorrhage, and intracranial brain tumor on CT or MRI scans. 5. Contraindications to antithrombotic and/or anticoagulant therapies.