Serologic Testing of Household Contacts of Confirmed Cases of COVID-19

Hospital Universitario Dr. Jose E. Gonzalez96 enrolled

Overview

SARS-CoV-2 has now crossed the 1 million number of cases and tens of thousands of deaths. It´s R0 has been calculated between 2 and 5.7 solely based on clinical symptoms but it is estimated to likely be higher. Serologic evidence of infection has not been analyzed.

Transverse, observational and descriptive study involving household contacts of documented patients with COVID-19 infection: contacts will be invited to participate and a blood sample will be drowned: IgM and IgG qualitative and quantitative measurements will be performed. Demographic data regarding age, comorbidities, calculated time spent before and after the patients diagnosis, isolation practices etc.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coronavirus Infection

Eligibility

Sex: ALLMin age: 1 YearHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Persons over 1 years of age. 2. .Meet COVID-19 confirmed case intradomestic contact definition: 1. Living in the same home as the patient with SARS-CoV-2 PCR test detected (nasopharyngeal and/or oropharyngeal swab) performed in the Acute Respiratory Infection Diagnostic Unit. 2. Living in the same home as the patient with a PCR test for SARS-CoV-2 Indeterminate (nasopharyngeal and/or oropharyngeal swab) performed in the Acute Respiratory Infection Diagnostic Unit and that the initial patient has positive IgM/IgG serology for SARS-CoV-2. 3. .Informed Consent. Exclusion Criteria: 1. .Have fever, cough, pharyngeal pain or clinically have symptoms compatible with COVID-19 at the time of recruitment. 2. .Autoimmune disease, cancer, neutropenia. 3. .Under 1 years of age. 4. .Patients who, in the investigator's opinion, should be excluded from the research protocol.

Locations (1)

Hospital Universitario José E. Gonzalez

Monterrey, Nuevo León, Mexico

Outcomes

Primary Outcomes

Identify antibodies

Identify the presence of IgM and IgG antibodies from intradomestic contacts of patients with Polymerase Chain Reaction for detected SARS-CoV-2 .

Time frame: 1 day

Secondary Outcomes

Determine antibody sensitivity

Determine the sensitivity of IgM and IgG antibody detection by ELISA in direct eastern contacts of patients with PCR for detected SARS-CoV-2.

Time frame: 1 day

IgM determination

Determine the presence of IgM antibodies by ELISA in direct eastern contacts of patients with detected SARS-CoV-2 PCR.

Time frame: 1 day

IgG determination

Determine the presence of IgG antibodies by ELISA in direct eastern contacts of patients with detected SARS-CoV-2 PCR.

Time frame: 1 day

Data from ClinicalTrials.gov

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