FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma

Inclusion Criteria: 1. сT4 cN0 or cT1-4 cN+ histologically proven adenocarcinoma of the esophagogastric junction (Siewert type II-III) or the stomach without distant metastases (M0) 2. No previous cytostatic chemotherapy or radiation therapy 3. Age 18-70 years (female and male) 4. Eastern Cooperative Oncology Group ≤ 2 5. Surgical resectability 6. Neutrophils\> 2.000/µl 7. Platelets \> 100.000/µl 8. Normal value of Serum Creatinin 9. Albumin level \> 29 г/л 10. Aspartate transaminase (AST) or alanine transaminase (ALT) less than 3 times the upper limits of normal (ULN) 11. Total Bilirubin less than 1.5 times the ULN 12. Written informed consent. Exclusion Criteria: 1. Previous cytostatic chemotherapy or radiation therapy 2. Distant metastases or all primarily not resectable stages 3. Cancer relapse 4. Complicated gastric cancer (perforation, bleeding, sub or decompensated stenosis, dysphagia IV) 5. Diarrhea ≥ 2 according to the criteria of Common Terminology Criteria for Adverse Events (CTCAE) version 4.1; 6. Hypersensitivity against 5- Fluorouracil, Leucovorin, Oxaliplatin, Epirubicin and Docetaxel 7. Existence of contraindications against 5- Fluorouracil, Leucovorin, Oxaliplatin, Irinotecan or Docetaxel 8. Active coronary heart disease, Cardiomyopathy or cardiac insufficiency stage III-IV according to New York Heart Association (NYHA) 9. Severe non-surgical accompanying disease or acute infection (uncontrolled arterial hypertension, diabetes mellitus, stroke less than 6 months old, mental disorders, other tumors and others) 10. Malignant secondary disease, dated back \< 5 years (exception: In-situ-carcinoma of the cervix uteri, adequately treated skin basal cell carcinoma) 11. Peripheral polyneuropathy \> Grad II 12. Liver dysfunction (AST)/ALT\>3,0xULN, ALT\>3xULN, Bilirubin\>1,5xULN) 13. Serum Creatinin \>1,0xULN 14. Chronic inflammable gastro-intestinal disease 15. Inclusion in another clinical trial 16. Pregnancy or lactation 17. Hepatitis B or C in the active stage 18. Human immunodeficiency virus(HIV) infected 19. Serious concomitant somatic and mental illnesses / deviations or territorial causes that may prevent the patient from participating in the protocol and observing the protocol schedule 20. Foreigners or persons with limited legal status