We hypothesize that serial changes of body composition in patients with pneumonia can help clinician to monitor prognosis. It was associated with underlying immune response.
Specific aims: 1. Can serial body composition data be useful for predicting outcomes of patients with pneumonia? (developing sepsis, organ failure, admission to ICU, length of ICU, survival, length of stay in hospital, prolonged mechanical ventilation,..) 2. Can serial body composition data be integrated into both immune status alternatives (e.g., white blood cell (WBC) count, segment/monocyte ratio, pulse pressure) in such critical illness and monitoring responses (SOFA score, labs) for severe pneumonia patients? 3. Can serial body composition data reflect clinical variables in patients with pneumonia, and even altered by nutrition intake? (e.g., compare association between nutrition intake amount and groups stratified by body composition, blood pressure, nutritional intake, …)
Study Type
OBSERVATIONAL
Enrollment
194
By means of noninvasively Bio-electrical Impedance Analysis (BIA) to measure body composition, which divides body weight into different components such as lean body mass and fat mass.
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
ICU Days
length of stay in ICU
Time frame: During hospitalization， "through study completion, an average of 1 year"
Ventilation days
days of mechanical ventilation
Time frame: up to 24 weeks
sepsis free days
the cure day of sepsis
Time frame: up to 24 weeks
mortality
death rate
Time frame: During hospitalization， "through study completion, an average of 1 year"
Change in Total Body Water
Change in Total Body Water
Time frame: Change from Baseline Total Body Water at day 8
Change in Percentage of Body Fat
Change in Percentage of Body Fat
Time frame: Change from Baseline Percentage of Body Fat at day 8
Change in Soft Lean Mass
Change in Soft Lean Mass
Time frame: Change from Baseline Soft Lean Mass at day 8
Change in segment/monocyte ratio
Change in Segment count to monocyte count ratio
Time frame: Change from Baseline Segment count to monocyte count ratio at day 8
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