Safety Study of Pritumumab in Brain Cancer

Inclusion Criteria Subjects must meet all of the inclusion criteria to participate in this study. 1. Ability to understand and the willingness to provide informed consent. 2. Diagnosis Histologically confirmed diagnosis of brain cancer: * glioblastoma (GBM), * anaplastic astrocytoma (AA), * anaplastic oligodendroglioma (AO), * anaplastic mixed oligoastrocytoma (AMO), * low grade gliomas, * brain metastases, * meningiomas, chordomas, medulloblastoma, craniopharyngiomas, pituitary tumors or * leptomeningeal metastases 3. Prior Therapy Has failed prior standard therapy including maximal safe surgical resection, radiation therapy (when appropriate for the specific cancer type), or systemic therapy or is intolerant of, or has refused other available therapies, but is still in need of therapy. No patients may receive Pritumumab prior to any surgery for their cerebral tumor 4. Progression/Recurrence Has progression of brain cancer and measurable disease by magnetic resonance imaging (MRI) or computed tomography (CT) scan. For leptomeningeal metastases, positive cytology is acceptable if imaging is not measurable. 5. Age Age ≥ 18 years. 6. Performance Status Karnofsky Performance Status ≥ 60% (see Appendix A). Subjects must have a life expectancy of equal to or greater than 8 weeks. 7. Organ and Marrow Function Requirements Hematology: * Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L * Platelet count ≥ 100 x 109/L * Hemoglobin ≥ 9.0 g/dL * White blood cell (WBC) count ≥ 3.0 x 109/L Biochemistry: * AST/SGOT and ALT/SGPT ≤ 5 x institution's ULN * Total bilirubin ≤ 3 x institution's ULN * Serum creatinine ≤ 2 x institution's ULN or 24-hour creatinine clearance ≥ 50 mL/min * Alkaline phosphatase (ALP) ≤ 3 x ULN unless considered tumor related * Estimated GFR \> 50 mL/min Coagulation: * INR ≤ 1.4 * PT/aPTT ≤ 1.2 x institution's ULN 8. Contraception All fertile females and any man with a partner of child-bearing potential agrees to use adequate contraception which will include two of the following: hormonal or barrier method of birth control, or abstinence prior to study entry, for the duration of study participation, and for 30 days following completion of therapy. 9. Although Pritumumab shows notable immunohistologic reactivity against active endometrial tissues, fertile female patients will be included in this study. Exclusion Criteria Subjects meeting any of the exclusion criteria at baseline will be excluded from study participation. 1. Current or anticipated use of other investigational agents. 2. Insufficient time for recovery from prior therapy: * less than 28 days from any prior cytotoxic investigational agent, * less than 14 days from any prior non-cytotoxic investigational agent, * less than 28 days from prior cytotoxic therapy (except 23 days from prior temozolomide at 5 day regimen and 14 days from prior temozolomide at daily regimen, 14 days from vincristine, 42 days from nitrosoureas, 21 days from procarbazine administration), * less than 7 days for non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, targeted therapies (radiosensitizer does not count), * less than 7 days for immunotherapy agents, e.g., DCVax, Celldex, PD1, etc. 3. Less than 3 weeks from surgery or insufficient recovery from surgical-related trauma or wound healing. 4. History of allergic reactions attributed to compounds of similar chemical or biologic composition to Pritumumab plus any patently atopic patients who have a history of having experienced an episode of allergic anaphylaxis. 5. Severe or uncontrolled medical disorder that would, in the investigator's opinion, impair ability to receive study treatment (i.e., uncontrolled diabetes, chronic renal disease, chronic pulmonary disease or active, uncontrolled infection). 6. Known diagnosis of human immunodeficiency virus (HIV) infection. 7. Impaired cardiac function including any of the following: * Congenital long QT syndrome or a known family history of long QT syndrome; * History or presence of clinically significant ventricular or atrial tachyarrhythmias * Clinically significant resting bradycardia (\< 50 beats per minute) * Inability to monitor the QT interval by ECG * QTc \> 450 msec on baseline ECG. If QTc \> 450 and electrolytes are not within normal ranges, electrolytes should be corrected and then the patient re-screened for QTc * Myocardial infarction within 1 year of starting study drug * Other clinically significant heart disease (e.g., unstable angina, congestive heart failure, or uncontrolled hypertension) 8. Any female patients who develop serious uterine hemorrhage during this study may need to be excluded from further treatment with Pritumumab.