Cannabidiol and Oral Contraceptive Pills: Exploring a Drug-Drug Interaction

Inclusion Criteria: * Have regular menses (every 21-35 days) * Not at risk for pregnancy (not sexually active, using a barrier method of birth control, using a copper IUD for birth control, have a partner with a vasectomy, have had a tubal ligation, or in a same sex relationship) * Generally healthy women between the age of 18 to 35 years old * English speaking Exclusion Criteria: * Active users of hormonal contraception 1. For combined methods, if they have recently stopped use, they must have had one normal menstrual cycle 2. For prior Depo-Medroxyprogesterone Acetate users, they must be off of the medication for 2 months and be having regular menstrual cycles * Pregnancy (less than 6 weeks prior), breastfeeding (less than 6 weeks prior), a. If participants have a normal menstrual cycle after these events, they may be considered for enrollment * Any absolute/relative contraindications to EE and LNG (MEC category 3 or 4 \[12\]) including impaired liver function, history of deep venous thrombosis, hypertension (\> 140/90), diabetes with vascular changes, migraines with aura or neurological changes, history of myocardial infarction, pulmonary embolus, stroke or breast cancer. * Use of CBD or THC products / Marijuana in the last 30 days * Use of a known CYP450 inhibitor or inducer (other medication) * BMI\>25 * Metabolic disorders including uncontrolled thyroid dysfunction and Polycystic Ovarian Syndrome * Impaired liver or renal function * Smoking/vaping/e-cigarettes * Prior bariatric surgery * Decisional impairment * Incarceration