The purpose of this study was to explore the effects of uric acid control on stone recurrence and renal function in patients with calculi of hyperuricemia through a prospective controlled study.
2020.1 -2020.12 patients with urolithiasis and hyperuricemia were enrolled in the urology department of our hospital (100 cases). The patients were informed of this study before operation and randomly divided into uric acid drug control group (n = 50) and non-drug control group (n = 50). The patients were followed up for 3 months, 6 months, 12 months and 18 months after operation. Informations as age, sex, height, weight, calculation BMI, past medical history, history of gout, diabetes, hyperthyroidism, calcium supplements will be recorded. Rapid blood glucose, serum total cholesterol, high density cholesterol, thyroid hormone detection, androgen, estrogen detection, serum sodium, potassium, chlorine, calcium, magnesium, phosphorus, serum uric acid will be tested. Renogram test to evaluate the change of single renal function. The stones burden will be followed-up with ultrasound or kub or CT plain scan.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
100
For the uric acid control group, except that lifestyle changes were the same as those in the uric acid non-drug control group, non-drug uric acid control group was given febuxostat to reduce uric acid synthesis. Febuxostat is taken at a dose of 40 mg three times a week.
All patients in the group are advised to live regularly after operation, drink plenty of water, drink more than 2000ml every day, reduce the intake of high purine food and fructose-rich beverages, increase the intake of fresh vegetables, control weight and exercise regularly
Shanghai Xuhui Central Hospital
Shanghai, Shanghai Municipality, China
Stone burdern stone burdern
Use ultrasound or kub or CT plain scan to follow up the patients.
Time frame: Change from the base line of the stone's volume and quantity at 3 months.
Stone burdern stone burdern
Use ultrasound or kub or CT plain scan to follow up the patients.
Time frame: Change from the base line of the stone's volume and quantity at 6 months.
Stone burdern stone burdern
Use ultrasound or kub or CT plain scan to follow up the patients.
Time frame: Change from the base line of the stone's volume and quantity at 12 months.
Stone burdern stone burdern
Use ultrasound or kub or CT plain scan to follow up the patients.
Time frame: Change from the base line of the stone's volume and quantity at 18 months.
Renal function
Total and partial renal function
Time frame: Change from the base line of GFR at 6 months after the operation.
Renal function
Total and partial renal function
Time frame: Change from the base line of GFR at 12 months after the operation.
Renal function
Total and partial renal function
Time frame: Change from the base line of GFR at 18 months after the operation.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.