This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
This study aims to examine the effect of cannabidiol (CBD), pre-treatment, as Epidiolex, on brain microglial activation in healthy human subjects using \[11C\]PBR28 PET imaging. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects. Lastly, this research study will also examine the relationship between brain microglial activation and central pain sensitization with CBD pre-treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
15
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Subjects will receive intravenous lipopolysaccharide.
A small dose of capsaicin will be administered by intradermal injection.
Connecticut Mental Health Center
New Haven, Connecticut, United States
RECRUITINGMicroglial activation using [11C]PBR28 PET imaging
Difference in microglial activation (\[11C\]PBR28 VT levels) between the 2 groups (e.g., CBD vs. placebo)
Time frame: 10 Days
Capsaicin-induced hyperalgesia
Difference in capsaicin-induced hyperalgesia between the 2 groups (e.g., CBD vs. placebo)
Time frame: 10 Days
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