Intra-articular Vancomycin Powder in Knee and Hip Arthroplasty

Inclusion Criteria: * Standard criteria for the implantation of primary total hip or knee replacement * Revision of an aseptic THA or TKA. * Adults \>18 years of age * Diagnosis of Osteoarthrosis (OA), Osteonecrosis (ON), Arthritis; or aseptic loosening of THA/TKA. * Subject is willing to consent to participate in the study * Subject is available for follow-up through at least 2 years * Subject has met acceptable preoperative medical clearance and is free of or treated for medical conditions that would pose excessive operative risk. * Subject who are fluent in English and / or French and able to understand their role in the study Exclusion Criteria: * Active, local infection or systemic infection. * Participation in any other pharmaceutical, biologic or medical device clinical investigation * Subjects with known allergy to vancomycin * Subjects unable to consent * Patient with skin pathology