The objective of this study is to assess the long-term outcomes after hospital admission with Covid-19 with respect to pulmonary function, physical capacity, imaging, quality of life and socioeconomic outcomes.
Patients will be invited to follow-up visits 3 and 12 months after hospitalization with COVID19. Inclusion will take place during 2020. We expect to enroll 180 non-ICU patients and 36 ICU patients.
Study Type
OBSERVATIONAL
Enrollment
218
After hospital admissions with COVID19 patients will come for two clinical visits to complete a number of questionnaires, pulmonary function testing, six-minute walk test, blood sampling and imaging of the lungs.
Aarhus University Hospital
Aarhus, Denmark
Regional Hospital, Holstebro
Holstebro, Denmark
Regional Hospital, Horsens
Horsens, Denmark
Regional Hospital, Randers
Randers, Denmark
Imaging of the lungs
Expert evaluation
Time frame: 3 months after discharge
Imaging of the lungs
Expert evaluation
Time frame: 12 months after discharge
Pulmonary function tests
Liter
Time frame: 3 months after discharge
Pulmonary function tests
Liter
Time frame: 12 months after discharge
Six-minute walk test
Walking distance (meters) and change in oxygen saturation.
Time frame: Performed 3 months after discharge
Six-minute walk test
Walking distance (meters) and change in oxygen saturation.
Time frame: Performed 12 months after discharge
Short Form-36 (SF-36) questionnaire
0-100 scale. The lower the score, the more disability.
Time frame: 3 months after discharge
Short Form-36 (SF-36) questionnaire
0-100 scale. The lower the score, the more disability.
Time frame: 12 months after discharge
Fatigue Assessment Score
10-50 score. The higher the score, the more fatigue
Time frame: 3 months after discharge
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Regional Hospital, Silkeborg
Silkeborg, Denmark
Regional Hospital, Viborg
Viborg, Denmark
Fatigue Assessment Score
10-50 score. The higher the score, the more fatigue
Time frame: 12 months after discharge
Cognitive sore (MOCA)
0-30. The lower the score, the more cognitive impairment
Time frame: 3 months after discharge
Cognitive sore (MOCA)
0-30. The lower the score, the more cognitive impairment
Time frame: 12 months after discharge
Hospital anxiety and Depression score (HADS)
0-21. The higher the score, the more risk of anxiety or depression.
Time frame: 3 months after discharge
Hospital anxiety and Depression score (HADS)
0-21. The higher the score, the more risk of anxiety or depression.
Time frame: 12 months after discharge
Comorbidities
Any pre-COVID-19 comorbidity and treatment with immmunosuppressants will be registered.
Time frame: 12 months after discharge
Blood sample at routine follow up.
Change in outcomes between discharge and follow-up visits will be evaluated
Time frame: 3 months after discharge
Blood sample at routine follow up.
Change in outcomes between discharge and follow-up visits will be evaluated
Time frame: 12 months after discharge
Biobanking of blood
Knowledge regarding COVID19 is drastically evolving. Biobanking makes it possible to investigate blood samples in the future corresponding to ongoing evidence.
Time frame: 3 months after discharge
Biobanking of blood
Knowledge regarding COVID19 is drastically evolving. Biobanking makes it possible to investigate blood samples in the future corresponding to ongoing evidence.
Time frame: 12 months after discharge