Bioactive Glass in the Treatment of Enamel White Spot Lesions

Rania Salah60 enrolled

Overview

the aim of this study is to evaluate the effectiveness of BiominF® and Novamin® in comparison to Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the treatment of enamel white spot lesions

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

White Spot Lesion of Tooth

Interventions

BiominFDRUG

in office application of bioactive glass followed by self administered application by the patient until a point of white spot remineralization is reached

NovaminDRUG

in office application of bioactive glass followed by self administered application by the patient until a point of white spot remineralization is reached

CPP-ACPDRUG

applied in accordance with the manufacturer's specifications

Eligibility

Sex: ALLMin age: 14 YearsMax age: 26 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Not less than 1 white spot lesion on the labial surface of teeth in the anterior region with code 2 International Caries Detection and Assessment System II (ICDAS-II) or less * Absence of any active periodontal disease. * Written informed consent Exclusion Criteria: * Known hypersensitivity/allergy to study products and/or materials used * teeth having deep carious lesions or extensive restorations * Unwillingness to be randomly assigned to 1 of the 3 treatment groups * Advanced periodontal disease.

Locations (1)

Faculty of Dentistry

Alexandria, Egypt

Outcomes

Primary Outcomes

Change in White spot lesions dimension

Quantified using computer-assisted analysis based on digital intraoral photographs

Time frame: 6 months: (Baseline, 1 week, 1 month, 3 months, 6 months)

Secondary Outcomes

change in lesion fluorescence

evaluated using diode laser fluorescence device (Diagnodent)

Time frame: 6 months: (Baseline, 1 week, 1 month, 3 months, 6 months)

Data from ClinicalTrials.gov

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