Using Laser light to detect COVID 19 virus particles in deep throat swab / nasal swab samples.
The investigators will develop novel primers to detect single virus particles in patient samples. The method involves the absorption of light by single virus particles giving a specific pattern. The investigators will develop the device to create a microdroplet of carrier fluid that is run through the trial device. The investigators will develop novel binding receptors for preferential capture of Coronavirus. The investigators will review the results of the novel test against the standard diagnostic test and identify virus particles in test negative subjects. The investigators will isolate the viral rna in test negative subjects and perform sequencing to find novel mutations that are not detected by the current test.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
250
detection of virus particles by light absorbtion patterns.
Somerset NHS Foundation Trust
Taunton, Somerset, United Kingdom
kappa value
level of agreement between novel test and standard test
Time frame: 6 months
sensitivity and specificity
test of accuracy for the result versus a validated sample set
Time frame: unknown this will require a centrally validated test set for known positives and negatives to be available estimated 1 year
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