Postoperative Safety Outcomes of Intraoperative Intracameral Preservative-Free Moxifloxacin Versus Levofloxacin

Peregrine Eye and Laser Institute114 enrolled

Overview

Comparative safety study of intracameral levofloxacin versus moxifloxacin for postoperative infection prophylaxis

Randomized clinical trial comparing corneal and retinal changes after intracameral levofloxacin or moxifloxacin administered at the end of surgery among eyes undergoing uncomplicated phacoemulsification.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

114

Conditions

Cataract Senile Endophthalmitis Antibiotic Side Effect Safety Issues

Interventions

Levofloxacin OphthalmicDRUG

0.1 ml of unpreserved 0.5% levofloxacin

Moxifloxacin OphthalmicDRUG

0.1 ml of unpreserved 0.5% moxifloxacin

Eligibility

Sex: ALLMin age: 21 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Eyes undergoing uncomplicated cataract surgery by phacoemulsification Exclusion Criteria: * Corneal opacities, corneal dystrophies, glaucoma, uveitis, retinopathy, optic neuropathy, concomitant infection (blepharitis, hordeolum, or conjunctivitis) or uncontrolled systemic disease and intraoperative complications that may affect visual outcomes were excluded from the study

Locations (1)

Peregrine Eye and Laser Instittute

Makati City, MM, Philippines

Outcomes

Primary Outcomes

Endothelial Cell Count

Change in endothelial cell count as measured by specular microscopy

Time frame: 3 months

Central Retina Thickness

Change in central retinal thickness as measured by spectral domain optical coherence tomography

Time frame: 3 months

Secondary Outcomes

Adverse Events

Onset of Adverse events following intervention

Time frame: 3 months

Data from ClinicalTrials.gov

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