Correlation of Serum Adalimumab Levels at an Administration of 40 mg Weekly vs 80 mg Every Two Weeks

Antibodies to Adalimumab (ADA)

Antibodies to Adalimumab will be tested for 12 weeks of treatment

Time frame: 12 weeks

Clinical response for Ulcerative Colitis

Simple Clinical Colitis Activity Index (SCCAI) (for UC) refers to disease symptoms during the previous week. It is composed of six domains. After recording, the clinician-based SCCAI is able to categorize two types of patients: patients with inactive disease (SCCAI\<5) and patients with active disease (SCCAI≥5).

Time frame: 12 weeks

Clinical response for Ulcerative colitis

Truelove Index (for UC), is composed of 6 variables. Clinical remission was defined as 1 or 2 stools per day without blood, absence of fever or tachycardia, a normal hemoglobin or "returning towards normal," a normal ESR or "returning towards normal," and gaining weight.

Time frame: 12 weeks

Clinical response for Crohn´s Disease

Harvey-Bradshaw Index (for CD) considers five parameters. For each parameter a specific score is assigned. A score below 5 is considered as clinical remission. A reduction of 3 points is considered as relevant to define clinical response.

Time frame: 12 weeks

Fecal calprotectin

Fecal calprotectin levels will be tested during the study

Time frame: 12 weeks

Blood acute phase reactants