GPED Regimen for Relapsed/Refractory or Advanced ENKTCL

Inclusion Criteria: * Histopathology and immunohistochemistry confirmed diagnosis of NK/Tcell lymphoma according to WHO 2016 criteria. * refractory or relapsed after initial remission, or stage III-IV de novo patients * PET/CT or CT/MRI with at least one objectively evaluable lesion. * General status ECOG score 0-3 points. * The laboratory test within 1 week before enrollment meets the following conditions: * Blood routine: Hb\>80g/L, PLT\>50×10e9/L. * Liver function: ALT, AST, TBIL ≤2 times the upper limit of normal. * Renal function: Cr is normal. * Cardiac function: LVEF≥50%, ECG does not suggest any acute myocardial infarction, arrhythmia or atrioventricular conduction above I Blocking. * Sign the informed consent form Exclusion Criteria: * Active infection requires ICU treatment. Concomitant HIV infection or active infection with HBV, HCV. Patients who are infected with HBV but not active hepatitis at the same time are notexcluded. * Significant organ dysfunction Pregnant and lactating women. * Those who were known to be allergic to drugs in the study regimen. * Patients with other tumors who require surgery or chemotherapy within 6 months. * Other experimental drugs are being used.