Resting Postural Tremor in Multiple Sclerosis

Charles University, Czech Republic30 enrolled

Overview

Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.

The aim of this study is to test whether specially developed accelerometer and gyroscope can differentiate pattern of resting postural tremor in healthy and people with multiple sclerosis. Spectral analysis and the correlation of the average signal spectra will be computed. Moreover, categorization based on the tremor component according to the maximum likelihood estimation will be done.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis

Interventions

Examination of tremor and upper hand functionsBEHAVIORAL

Participants will be only examined. They will not undergo any intervention.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Group 1: * Definite diagnosis of MS * prevailed motor deficit of upper extremities, but without visible tremor * stable clinical status in the preceding 3 months * Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and * no corticosteroid therapy in the preceding month Group 2: * Healthy volunteers in the age of 20-70 years will be employed * There will be defined as persons without any neurological disease diagnose at the time of the measurement. Exclusion Criteria (both groups): Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.

Locations (3)

Department of neurology

Prague, Czechia

RECRUITING

Kamila Řasová

Prague, Czechia

RECRUITING

Deparment of revmatology and rehabilitation

Prague, Czechia

RECRUITING

Outcomes

Primary Outcomes

Tremor

accelerometer (1 m·s-2)

Time frame: baseline

Secondary Outcomes

Hand grip strength

Hand dynamometer JAMA

Time frame: baseline

Hand and arm function

Nine Hole Peg Test

Time frame: baseline

Psychomotor processing speed

Coin Rotation Task

Time frame: baseline

Central Contacts

Kamila Řasová, Ph.D.

CONTACT

+420604511416 kamila.rasova@gmail.com

Data from ClinicalTrials.gov

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