Vitamin D Testing and Treatment for COVID 19

Arizona State University41 enrolled

Overview

This study will measure vitamin D levels in adults with COVID 19. Participants with low levels of vitamin D will be entered into an open label trial of supplementation with vitamin D.

Protocol for Part 1: * A single blood draw at SCNM to measure levels of vitamin D and other nutrients, comprehensive metabolic panel, and complete blood count with differential * Completing a medical history/symptom form * Completing a form about COVID-19 symptoms every 2 weeks for 6 weeks * Authorization for release of medical records related to COVID 19 testing and/or treatment. Protocol for Part 2: * Take a vitamin D supplement daily for two weeks, at a dosage of 10,000 IU/day b.i.d. (age 18-69 years) or 15,000 IU/day t.i.d. (age 70+) * After two weeks of taking vitamin D, return to SCNM for a blood draw to remeasure levels of vitamin D, comprehensive metabolic panel, and complete blood count with differential. If vitamin D levels are still below 30 ng/ml, continue the dosage for 3 more weeks. If vitamin D levels are 30-49 ng/ml, continue at a dosage of 5000 IU/day. If vitamin D levels are 50+ ng/ml, stop supplementation. * Completing questionnaires about COVID 19 symptoms at 2, 4, and 6 weeks after treatment begins (5 minutes each time).

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Covid 19 Vitamin D Deficiency

Interventions

Vitamin D3DIETARY_SUPPLEMENT

Oral vitamin D3 capsules

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria for Part 1 (testing): 1. Adult age 18 or older 2. Previous positive test result for COVID 19 3. Able to communicate clearly in English Exclusion Criteria for Part 1 (testing): none Inclusion Criteria for Part 2 (Vitamin D supplementation) 1. Participation in Part 1 2. Vitamin D level below 30 ng/ml 3. No abnormalities on the comprehensive metabolic panel that are clinically significant to increasing the risk of an adverse reaction to vitamin D supplementation Exclusion Criteria for Part 2 (Vitamin D supplementation): 1. Liver impairment 2. Clinical opinion of study physician that vitamin D supplementation could be harmful to the participant. 3. Pregnancy 4. No symptoms for 2 weeks after positive COVID 19 test 5. Recovered from symptoms

Locations (1)

Arizona State University

Tempe, Arizona, United States

Outcomes

Primary Outcomes

Vitamin D levels

change in level of Vitamin D, 25-Hydroxy between the two time points

Time frame: baseline and after two weeks of vitamin D supplementation

severity of COVID 19 symptoms

We will calculate the change in severity of COVID 19 symptoms from baseline to 2 weeks after vitamin D supplementation

Time frame: baseline and at 2 weeks after vitamin D supplementation

Data from ClinicalTrials.gov

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