Anesthesia on Optic Nerve Sheath Diameter

Bursa Yuksek Ihtisas Training and Research Hospital80 enrolled

Overview

Different amounts of anesthetic gas can be used in the obstetric gynecological surgery operations to be performed with open method. Researchers aimed to compare the effect of gas changes on intraocular nerve diameter by ultrasonography.

A total of 80 patients who underwent laparotomic gynecological surgery were divided into two groups prospectively: high flow of 2 L/min and minimal flow of 0.5 L/min. Anesthesia was maintained with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 1 (n=40) and with 50% oxygen-50% air at 2 L/min and desflurane at 1.1 MAC in Group 2 (n=40). After 10-15 minutes, group 2 was administered minimal flow with 50-60% oxygen-40-50% air at 0.5 L/min and desflurane, and 10 minutes before the end of the surgery, the patients were switched to high flow with 50% oxygen-50% air at 2 L/min.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Optic Nerve Sheath Diameter

Interventions

The Effect Of Minimal and High Flow Anesthesia on Optic Nerve Sheath DiamaterPROCEDURE

The patients were randomly allocated to one of the two groups of fresh gas flows using the closed-envelope technique: 2 L/min high flow and 0.5 L/min minimal flow.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18-65 years * ASA I-II * Who underwent laparotomic gynecological surgery Exclusion Criteria: * Patients with obstructive pulmonary disease * Patients with decompensated diabetes, those with a fasting period of more than 12 hours -Acute alcohol intoxication * Chronic alcohol use * Who refuse to participate in the study * Who are not cooperative, do not speak Turkish * Who had known eye disease (glaucoma, retinal detachment), had a previous history of eye surgery, * Increased intracranial pressure findings (intracranial lesion, previous cerebrovascular diseases * Body mass index of \> 40kg/m2 * ASA \> III

Locations (1)

University of Health Sciences Bursa Yüksek İhtisas Training and Research Hospital

Bursa, Turkey (Türkiye)

Outcomes

Primary Outcomes

Optic Nerve Sheath Diamater

Optic nerve sheath diamater measurements of the patients were recorded before and during the surgery at specified time points (T0: awake, T1: High fresh gas flow after induction at the 10th min., T2: Inhalation anesthesia at the 30th min., T3: Inhalation anesthesia at the 60th min., T4: Inhalation anesthesia at the 90th min., T5: Before extubation).A typical optic nerve sheath is generally less than 5 mm in diameter, and diameters greater than 5.5 mm predict an ICP of ≥20 cm H2O with 100% sensitivity and specifity

Time frame: 2 hours operation time

Secondary Outcomes

Peroperative Complications

Complications during the surgery (decreased oxygen levels, hypercapnia, hypotension, hypertension, bradycardia, tachycardia, rhythm disorders) were recorded.

Time frame: 2 hours operation time

Postoperative Complications

Complications in the recovery room (respiratory distress, decreased oxygen levels, hypotension, hypertension, bradycardia, tachycardia, vomiting, rhythm disorders) were recorded.

Time frame: postop 20 minutes

Data from ClinicalTrials.gov

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