Dyspnea in Stable Patients With Coronary Artery Disease.

National Research Center for Preventive Medicine200 enrolled

Overview

Single-centre prospective study to characterize causes of dyspnea in stable patients with coronary artery disease and evaluate the possibility to determine the cause of dyspnea before in-depth examination.

Stable patients with dyspnea and coronary artery disease will be included in this single-centre prospective study. In addition to routine clinical examination patients will be interviewed to determine the nature of shortness of breath, angina, presence of chronic heart failure or anxiety using the Medical Research Council Dyspnea scale, the visual analog scale of dyspnea, Borg scale, modified "dictionary" of dyspnea, G. Rose questionnaire, Seattle Angina Questionnaire, Framingham criteria for chronic heart failure and the SHOCK scale. During the subsequent in-depth examination including thyroid hormones, NT-proBNP, hsTroponin, ECG monitoring, six-minute walk test, stress-echo with a diastolic stress test, spirometry and coronary angiography (if necessary) main reason for dyspnea will be established. Possibilities of early (before in-depth examination) determination the reason for dyspnea in stable patients with coronary artery disease will be evaluated.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Dyspnea Coronary Artery Disease

Interventions

Scales for assessment of symptomsDIAGNOSTIC_TEST

Medical Research Council Dyspnea scale, the visual analogue scale of dyspnea, Borg scale, modified "dictionary" of dyspnea, G. Rose questionnaire, Seattle Angina Questionnaire, Framingham criteria for chronic heart failure, the SHOCK scale.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. Stable patients with shortness of breath and established diagnosis of coronary artery disease (at least 1 of the following signs): * history of myocardial infarction; * typical angina without suspected other cause of pain; * myocardial ischemia documented by ECG changes during symptoms and/or by results of the stress test; * coronary artery stenosis \>50% according to coronary angiography. 2. Signed informed consent. Exclusion Criteria: 1. Acute coronary syndrome (myocardial infarction, unstable angina) in the previous month. 2. Hospitalization with decompensation of CHF in the previous 6 months (including CHF decompensation as the main reason for current hospitalization). 3. Diseases with an unfavourable prognosis (terminal CKD, CHF NYHA IV, a lung disease with severe respiratory failure). 4. Contraindications to bicycle stress echocardiography. 5. Atrial Fibrillation at the time of hospitalization, when the decision not to restore the sinus rhythm. 6. Mental illnesses and disorders, dementia, drug or alcohol dependence. 7. Known oncological diseases.

Locations (1)

National Research Centre for Therapy and Preventive Medicine

Moscow, Russia

Outcomes

Primary Outcomes

Myocardial ischemia as a reason of dyspnea

Number of patient with dyspnea related to myocardial ischemia

Time frame: up to 1 month

Secondary Outcomes

Other causes of dyspnea

Number of patient with non-ischemic reasons for dyspnea (heart failure, pulmonary disease, arrhythmias, psychogenic, mixed or undetermined cases).

Time frame: up to 1 month

Adverse events

Composite of death, myocardial infarction, stroke and rehospitalization

Time frame: 6 months

Data from ClinicalTrials.gov

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