Glucose Metabolism After Partial Pancreatectomy

Seoul National University Hospital224 enrolled

Overview

This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.

Biochemical markers of glucose metabolism including oral glucose tolerance tests, fasting blood glucose, insulin, glucagon and HbA1c were performed on patients receiving pancreatectomy (pancreaticoduodenectomy and distal pancreatectomy). Tests were done preoperatively, postoperatively at 3 months, and at 1 year. The primary endpoints were the incidence and risk factors of new-onset and worsened DM after each type of pancreatectomy.

Study Type

OBSERVATIONAL

Enrollment

224

Conditions

Pancreatectomy; Hyperglycemia Diabete Mellitus

Interventions

oral glucose tolerance testDIAGNOSTIC_TEST

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * partial pancreatectomy Exclusion Criteria: * total pancreatectomy * incomplete testing * follow-up loss * death within 1 year

Outcomes

Primary Outcomes

incidence & risk factors of new-onset DM

incidence \& risk factors of new onset DM after pancreatectomy

Time frame: at 1 year

incidence & risk factors of worsened DM

incidence \& risk factors of worsened DM after pancreatectomy

Time frame: at 1 year

Secondary Outcomes

characteristics of new-onset and worsened DM

changes of glucose metabolism during study period

Time frame: 1 year

Data from ClinicalTrials.gov

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