Association Between Telomere Length and Cardiac Dysfunction

Air Force Military Medical University, China300 enrolled

Overview

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Cardiac Toxicity Acute Leukemia Childhood Cancer

Interventions

Relative telomere lengthDIAGNOSTIC_TEST

Relative telomere length in peripheral blood cell

Eligibility

Sex: ALLMin age: 1 YearMax age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\. histological confirmed acute leukemia; 2. Preparing for chemotherapy; Exclusion Criteria: * 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Locations (1)

Xiao-Fan Zhu

Tianjin, Tianjin Municipality, China

Outcomes

Primary Outcomes

Relative telomere length

The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.

Time frame: From date of admission until the date of discharging from hospital, assessed up to 5 days

Data from ClinicalTrials.gov

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